Cobram Crime Investigation Unit detectives, local uniform members and the dog squad executed four warrants in Cobram on Wednesday.
Warrants were executed at addresses in Charles Street, Acacia Street, Ovens Court and William Street.
Police arrested two men and one woman in relation to the investigation.
A 27-year-old man was charged with possess drug of dependence and cultivate drug of dependence.
A 32-year-old female was cautioned for possessing cannabis.
A 25-year-old male was charged with theft of motor vehicle.
Police have a number of other operations planned in the local area in the near future.